Can Prednisone make a little girl morph into Lucrezia Borgia? I'm worried she may attempt to poision someone. Maybe it's the lack of sleep brought on by the Prednisone that's making her evil. I don't know. I only know I'm glad we've only got 2 doses & a day and a half left. I can't take much more of this. None of us can. The mini-dictator bit is getting old really fast! And our eardrums are permanetly damaged...I'm sure of it.